Solumarv, INN - insulin human

Abasria, INN-insulin glargine

Clopidogrel Protects Endothelium by Hindering TNFα-Induced VCAM-1 Expression through CaMKKβ/AMPK/Nrf2 Pathway

Clopidogrel (INN), an oral antiplatelet drug, has been revealed to have a number of biological properties, for instance, anti-inflammation and antioxidation. Oxidative stress plays an imperative role in inflammation, diabetes mellitus, atherosclerosis, and cancer. In the present study, human aortic endothelial cells (HAECs) were employed to explore the anti-inflammatory activity of INN. INN red...

Crystallographic analysis of human hemoglobin elucidates the structural basis of the potent and dual antisickling activity of pyridyl derivatives of vanillin. Corrigendum

Vanillin has previously been studied clinically as an antisickling agent to treat sickle-cell disease. In vitro investigations with pyridyl derivatives of vanillin, including INN-312 and INN-298, showed as much as a 90-fold increase in antisickling activity compared with vanillin. The compounds preferentially bind to and modify sickle hemoglobin (Hb S) to increase the affinity of Hb for oxygen....

Veraseal, INN-human fibrinogen / human thrombin

The mechanism of action of human accelerator globulin and its relation to other clotting factors.

By MERLE LOVELL LEWIS, PH.D. AND ARNOLD G. WARE, P11.1). T HE CONCEPT of blood coagulationi has undergone drastic revision inn the past decade. A number of different names have beenn gin-cnn to the substannces in serum arid plasma w-hich accelerate the comnversiomn of prothrombin to thrombimn. In ann effort to resolve some of the resultant comnfusiomn inn nomenclature, the Josiah Macy Conferenc...